Intraventricular rifampicin in severe tuberculous meningo-encephalitis.

نویسندگان

  • W Vincken
  • M Meysman
  • D Verbeelen
  • S Lauwers
  • J D'Haens
چکیده

We present a patient acutely ill from severe tuberculous meningo-encephalitis, in whom acute hepatic and renal failure, due to intercurrent septic shock, precluded the administration of full systemic dosage of antituberculous drugs. Daily direct intraventricular administration of 5 mg rifampicin, via a subcutaneous Ommaya reservoir connected to a catheter placed in the right lateral cerebral ventricle, resulted in rapid improvement without neurological sequelae. Intraventricular rifampicin administration for 50 consecutive days was well-tolerated without local or systemic side-effects. In well-selected patients with severe tuberculous meningo-encephalitis, intraventricular rifampicin may safely and highly effectively be added to systemic antituberculous therapy.

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عنوان ژورنال:
  • The European respiratory journal

دوره 5 7  شماره 

صفحات  -

تاریخ انتشار 1992